产品货号：
Z20999
中文名称：
MKK7/MAP2K7抗体
英文名称：
Anti-MKK7/MAP2K7 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-MKK7/MAP2K7 Antibody |
| 指标别名 | JNK activating kinase 2;JNK kinase 2;JNKK 2;Jnkk2;MAP kinase kinase 7;MAP2K7;MAPK/ERK kinase 7;MAPKK 7;MAPKK7;MEK 7;MEK7;MKK7;PRKMK7 |
| 克隆性 | Polyclonal |
| 检验物种 | human,monkey,mouse,rat |
| 应用范围 | WB,FCM |
| 基因名称 | MAP2K7 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the N-terminus of human MEK7(24-40aa ARRRIDLNLDISPQRPR),identical to the related rat and mouse sequences. |
| 实际分子量 | 47KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | MAP2K7(Mitogen-activated protein kinase kinase 7),also known as MAP kinase kinase 7,MAPKK7,JNKK2,PRKMK7 or MKK7,is an enzyme that in humans is encoded by the MAP2K7 gene.This protein is a member of the mitogen-activated protein kinase kinase family.The MKK7 protein exists as six different isoforms with three possible N-termini(alpha,beta,and gamma isoforms) and two possible C-termini(1 and 2 isoforms).Schramek et al.(2011) showed that the doxorubicin-mediated DNA damage response in human A549 lung carcinoma cells caused rapid phosphorylation and upregulation of p53(TP53).MKK7 knockdown reduced p53 phosphorylation,delayed p53 upregulation,and interfered with cell cycle arrest at G2/M.MKK7 was activated in primary lung tumors,and tumors with a p53 mutation showed even higher MKK7 phosphorylation.Schramek et al.(2011) concluded that MKK7 exerts its tumor suppressive function through p53. |
| Uniprot ID | O14733 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | mitogen-activated protein kinase kinase 7 |
| 蛋白名全称 | Dual specificity mitogen-activated protein kinase kinase 7 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Flow cytometry (FCM) 1～3μg/1×106 cells |
相关搜索：MKK7/MAP2K7抗体，MKK7抗体，MAP2K7多抗，Anti-MKK7/MAP2K7 Antibody